Manufacture of harmless combinations of sulfocyanic acid.



outrun sTATEs rATEN O CE JOSEPH nnnxmo, or DUSSELDORF, GERMANY, Assieuon r0 onnmscnn FABRIK nEIsHoLz, e. M. B. 11., 0F nussnLnonr-nnrsnoLz, GERMANY.

MANUFACTURE or HAnMLE ss No Drawing.

To all whom it may concern:

Be it known that I, JosnPI-I NERKING, a

citizen of the Empire of Germany, residingbeen employed as prophylactics against the decomposition of teeth and the mycodermitis, also as antispasmodics and sedatives, but they are objectionable on account of their POlSOllOUSIlBSS, for which reason they are nearly no longer employed.

My invention relates to the manufacture of new combinations of sulfocyanic acid, which are harmless and therefore suitable for medical purposes.

The invention essentially consists in the combination of salts of sulfocyanic acid with albumin of any description, either alone or in conjunction with other substances.

When salts of sulfocyanic acid'are mixed with albumin in the dry or moist condition or with solvents, solid gummy bodies or solutions of the same respectively will be formed, which bodies when dry are partly difficultly soluble in water or -spirit of wine and partly insoluble. The soluble part of the bodies coagulates on boiling the solution, also on the addition of stronger acids, while the insoluble part simply swells up in water. Both parts contain more or-less sulfocyanic acid (HCNS)- in proportion to the concentration of the reacting solutions. Such combinations of the sulfocyanic acid may be formed from animal albumins (ovalbumin, casein) as well as from vegetable albumins; however, the casein and the vegetable albumins require to be first. dissolved by the additionof an alkali or an alkaline earth, such as for example carbonate of sodium or hydrate of lime.

- The mixing of' the salts of sulfocyanic" acid withalbumin ground as finely as possible does not present any difficulties, providedthat the quantities are small; the mixture agglomerates and. forms a plastic mass, which is dried at'a moderate temperature, preferably at 40 Centigrade. When the q'iuintities are a little larger, it is advisable to add so much water or Specification of Letters Patent. Application filed May 2, 1911. Serial No. 624,602.

rather spirit of coMnINA'rIoNs OF SULFOCYANIC dm.

Patented Dec. 5; 1911.

wine as to render the mixing easy. T ff. larger quantities it is best't-o let the two components, v z. the albumin and-the saltof sulfocyanic acid, act upon each otherina;

watery solution, or the saltjof sulfocyanio acid may be addedundissolved-oiirQan.'

alcoholic solution. Thesolution ',may be i. concentrated and dried up by evaporation in! wucuo at a temperature of under 50.9 centi;

grade, or the sulfocyanate of albumin may be separated with theaid of spirit of wine as a gummy coagulated mass, which can be easily dried up at about 40 centigrade.

When to a concentrated solution of albiiw min a. larger quantity of undissolved salt of sulfocyanic acid is added, the whole mass will coagulate and the sediment can be sepaili ratedby pressing, washed out with alittle] spirit of wine and dried at40 centigrade.' This is for example the case, if the concen trated solution of albumin is made by di ssolving 2' kilograms of dry 'ovalbumin in 5- liters of water, and from 4 to 5 kilo rams of sulfocyanate of ammonium are added to this solution. The preparation so obtained contains about 33%0f HG'NS and can be mixed with any quantityv of powdered albumln so as to obtain any percentage of HGNS required by the physician. I "The last named method has been found to be the most preferable for large quantities and for preparations richest in sulfocyanate of albumin.

It does not matter, whether sulfocyan'ate of ammonium or sulfocyanate of potassium or sulfocyanate of sodium or sulfoc'yanate of calcium or sulfocyanate of strontiu'm or any other salt of sulfocyanic acid be employed in the process, since in the combine ti'on with the albumin only the sulfocyanic acid-is a considerable component. I claim: i

1. The method of manufacturing harm less combinations of sulfocyanic acid, which, consists in mixing an albumin with a salt of sulfocyanic acid, and drying the mass.

2. The method of manufacturin harm-j less combinations of sulfocyanic acid, ,which consists in dlssolvingan albumin-in a solvent, mixing the solution with a salt of 'sul focyanio acid, anddrying themass.

3. The meth'o'd of manufacturing harm? less combinations of sulfocyanic acid, which consists in dissolving ,an albumin in a sol:

vent, adding a salt of sulfocyanic acid,thick ening tl ie resulting-solution by evaporation combination by, evaporation in vacuo, and\ in wacuo, and drying the mass. drying the mass. @[Th method of manufacturing harmless combinations of sulfocyanic acid, which JOSEPH NERKING 5 consists in dissolvin an albumin in a sol- Witnesses; vent, addin'g van a10101ic splutlon of a salt ALFRED HENKEL, oi sulfocyanic acsid, thickening the resulting J ULIN BERGER, 

